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Optical Bio-Sensing Laboratory

Texas A&M University College of Engineering

Capabilities

Capabilities

From photon to prototype

Materials, electronics, validation and analytics, all designed, built and tested in house.

Multimodal wearables

Patches, bands and textiles combining ECG, PPG, bioimpedance, pressure, thermal and motion sensing.

Embedded electronics

Custom PCBs, analog front ends, low-power firmware, and BLE, Wi-Fi, mesh and encrypted RF links, designed in house.

Physical & digital twins

Anatomical phantoms with controlled flow, paired with computational models of the same tissue, for repeatable, predictive sensor testing.

Optical & electrochemical sensing

Raman, fluorescence and polarimetry, plus aptamer and antibody electrochemical biosensors for continuous biomarker and glucose detection.

Neural interfaces

EEG, EMG and EOG acquisition, neural feedback and validation platforms for brain and muscle signals.

AI & signal processing

Machine learning and physiological modeling that turn raw signals into clinically meaningful measurements.

GATEWAYChest patchEEG headsetFinger ringWristbandGait sockGloveHOSPITALNETWORK / EHRPHONE APPBLEWI-FIMESHENCRYPTED

Connectivity

Any device, any link, encrypted.

Any OBSL device can be built with Bluetooth Low Energy, Wi-Fi, mesh networking or other RF protocols, with encrypted links from the sensor to the software.

  • Bluetooth Low Energy. Low-power links to phones, tablets and our desktop apps.
  • Wi-Fi. Direct connection to hospital and lab networks for streaming and data offload.
  • Mesh networking. Many wearables on one person or many patients relay data to each other, with seamless handoff between links.
  • Secure by design. Encryption protocols and authenticated pairing on every link.
DATA PATH · SENSOR TO STUDYSENSORraw signalENCRYPTAES linkDE-IDENTIFYcoded IDPLATFORMHIPAA · FERPAANALYZEsecure GPUIRB OVERSIGHT · CUI/PHI CONTROLSINDEPENDENT THIRD-PARTY AUDITNO FACES · NO VOICES · MINIMAL DEMOGRAPHICS

Data protection

Protected from the sensor to the study.

Physiological data is personal. Every OBSL study is designed so that partners, sponsors and participants can see exactly how it is collected, protected and shared.

  • IRB-governed. Every human study runs under Texas A&M Institutional Review Board oversight with informed consent.
  • De-identified by default. Participants are stored under coded IDs with minimal demographics. No faces, no voices.
  • Compliant platform. Research data lives on a HIPAA- and FERPA-compliant, commercial-grade platform with controlled sharing, including CUI and PHI handled within their frameworks.
  • Secure compute. Sensitive analysis runs in a compartmentalized, high-performance GPU environment at Texas A&M.
  • Independently audited. Data-protection practices are validated by third parties, not by us, so partners never have to take our word for it.
  • Interoperable on your terms. Documented packet formats and APIs deliver data into enterprise health and research systems, from EHRs to MHS GENESIS.

Neural interfaces

Reading brain, eye and muscle.

We build wearable biopotential systems for EEG, EOG and EMG, from electrodes and low-noise front ends to real-time processing, feedback and validation platforms.

EEGBrain rhythmsEOGEye movement and blinksEMGMuscle activationlook left, look right, blinkFzOzHEOGVEOGBiceps EMG
EEGBrain rhythms and responses for cognitive state, fatigue and neurological monitoring.
EOGEye movements and blinks for attention, fatigue and hands-free control.
EMGMuscle activation for performance, rehabilitation and gait analysis.
Neural feedbackClosing the loop between what the body signals and how the system responds.

Gait & movement

Smart socks that read how you walk.

Our sensing socks measure every step, mapping pressure from heel strike to toe-off on both feet, to track subtle gait changes linked to Parkinson’s disease, Alzheimer’s disease and other neurological conditions, continuously and at home.

  • Soft, sock-integrated sensing. Flexible and liquid-metal pressure sensors built into a comfortable sock.
  • Clinically meaningful metrics. Cadence, stride timing, stance and swing, and left-right symmetry.
  • Connected. IoT streaming for long-term monitoring of disease progression outside the clinic.

Gait research →

PLANTAR PRESSURELRGAIT CYCLELEFTRIGHTCADENCE102/minSTRIDE1.18 sSTANCE61 %SYMMETRY0.97STREAMING TO APP | AT HOME

Physical & digital twins

Tested twice before it touches a patient.

Every sensor we design is evaluated on a physical twin, an anatomical phantom with controlled blood flow and pressure, and on a digital twin, a computational model of the same tissue and device.

  • Mechanics. Contact pressure, tissue deformation and strain at the sensor interface, simulated before we build.
  • Electrical. Electrode–skin impedance, current paths and field distribution for ECG and bioimpedance designs.
  • Closed loop. Phantom measurements calibrate the models, and the models predict the next design.
Physical twinDigital twinvalidatecalibrateSilicone phantom, controlled flowMechanical + electrical
Baseline scanTarget binds: current dropsRegenerate: sensor resetsGold working electrodeE (V)i (µA)redox tagtargetantigen

Electrochemical biosensing

Molecules in, signal out, reset, repeat.

Our electrochemical sensors use aptamers and antibodies anchored to an electrode to detect specific molecular targets, then release them so the same sensor can measure again.

  • Aptamer sensors. DNA and RNA strands fold when they bind their target, changing electron transfer from a redox tag.
  • Antibody sensors. High-specificity capture of protein biomarkers such as cardiac troponin.
  • Regenerable. Bound targets are released so the electrode re-senses, a path to continuous molecular monitoring.
  • Readout. Cyclic and square-wave voltammetry and impedance spectroscopy.

Nanoparticle & nucleic acid sensing

Amplify without enzymes. Read with light.

Engineered DNA probes on gold nanoparticles recognize cardiovascular biomarkers, then trigger an enzyme-free isothermal amplification that pulls the nanoparticles together. The plasmonic hot spots between them boost Raman signals for sensitive, multiplexed detection outside the central lab.

  • Nucleic acid engineering. Programmable DNA probes designed for specific cardiovascular disease biomarkers.
  • Enzyme-free amplification. Isothermal reactions that run without enzymes or thermocyclers.
  • SERS readout. Surface-enhanced Raman spectroscopy gives each reporter its own spectral fingerprint, so several biomarkers are read at once.
  • Built for low-resource settings. Sensitive detection without a central laboratory.
1 Target binds probe2 Enzyme-free amplification3 Laser excites hot spotsSERS spectrumRaman shift (cm⁻¹)biomarker ABCgold nanoparticleDNA hairpintarget

Backed by Texas A&M

A university built to work with the Department of Defense.

OBSL is one lab inside the Texas A&M Engineering Experiment Station, a research agency with the offices, infrastructure and contracting vehicles to take a sponsored project from idea to fielded system.

StAR

TEES Strategically Aligned Research offices

Large-scale, cross-disciplinary project offices led by TEES Associate Agency Directors. Dr. Coté directs Health and Human Performance; sibling offices cover National Security, Space and CHIPS.

Learn more →
INSPIRE

INSPIRE Alliance

A TEES-affiliated 501(c)(3) established by the Texas A&M Board of Regents to contract directly for applied national security research with the Department of Defense and industry, at high speed and large scale.

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CRHTS

Center for Remote Health Technologies and Systems

The TEES center OBSL grew out of, directed by Dr. Coté, engaging regulators, clinicians and industry to design, test and deploy remote health systems.

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NSF ERC

PATHS-UP Engineering Research Center

The NSF Engineering Research Center led by Texas A&M with UCLA, Rice and FIU, building affordable point-of-care and wearable technologies for chronic disease.

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SECURE

Compliant data and secure computing

HIPAA- and FERPA-compliant research data platforms with controlled sharing of CUI and PHI, and a compartmentalized high-performance GPU environment for sensitive analysis.

BCDC

Bush Combat Development Complex

The George H.W. Bush Combat Development Complex at the RELLIS Campus, built with the Army to prototype, test and field defense technology minutes from the lab.

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MIL-MED

College of Medicine Military Medicine

Texas A&M’s military medicine program and its annual Military Medicine Engagement Day, connecting cadets, service academies and military physicians with campus research.

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IRB

Human research oversight

Texas A&M Institutional Review Board governance for every human study, with de-identified data handling and independent third-party audit of data protection.

Patented innovation

Known for sensor patents.

OBSL inventors hold patents and invention disclosures across wearable biosensing, physiological monitoring and device validation, and our technologies have moved into licensing and startup ventures.

Wearable biosensingCuffless blood pressure, multimodal patches and bands.
Monitoring systemsSignal acquisition, processing and continuous physiological measurement.
Molecular sensingOptical and electrochemical biomarker and glucose detection.
Validation platformsAnatomical phantoms and test systems for medical devices.

From idea to impact

Concept to clinic, under one roof.

We carry technologies through every stage of translation, with cost, manufacturability and deployment in mind from day one.

01

Concept

Clinical and operational needs drive the sensing approach.

02

Prototype

Rapid hardware, firmware and materials iteration.

03

Bench validation

Phantom systems with controlled flow and pressure.

04

Studies

Human and animal studies with clinical collaborators.

05

Translation

Disclosures, patents, licensing and startups.

© 2016–2026 Optical Bio-Sensing Laboratory Log in

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