Sungyub Han joined Dr. Cote’s lab October 2016 as a post-doc Research Associate. I received Ph.D in Chemistry from University of South Florida at Tampa in 2015 and performed analysis of drug products at Xcelience in Tampa before joining Dr. Cote’s Lab. My research area has been using Surface-enhanced Raman Scattering (SERS) to characterize bio-molecules and synthesis of gold, silver, and silica nanoparticles. Now, I have involved in a project: the oral cancer biosensor using SERS-based vertical flow assay (VFA) as a Point-of-Care device. Briefly, we employs gold nanoparticle conjugated with single strain oligonucleotide probes. The oligonucleotide probes on gold nanoparticles are designed to bind to oral cancer biomarkers (S100P mRNA, etc) as a sandwich formation with its high specificity. The hybridization of the bio-markers both in free-solution and on VFA is monitored by Raman spectroscopy producing strong Raman signals. This SERS-based VFA has attractive advantages such as user-friendly, high sensitivity, cost-effective, and rapid analysis.